The fire was reported just before 7am ET. New York City fire officials said the blaze broke out in the building’s heating and air conditioning system and injured two people.
A civilian was treated for serious injuries and a firefighter was treated for minor injuries, officials said. It took about an hour to put out the fire.
News footage showed firefighters on the roof of the skyscraper, at East 57th Street and Fifth Avenue in Manhattan.
Smoke billowed from one corner of the high-rise for a while before most of it dissipated. About 84 firefighters were at the scene initially. A few remained on the roof about an hour later.
The tower is home to a number of residences and businesses. Donald Trump, who keeps a residence in the tower, was at the White House in Washington DC.
One of the president’s sons, Eric Trump, tweeted his thanks to firefighters for doing “an incredible job”.